Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats

OBJECTIVES: Oxidative stress with subsequent lipid peroxidation (LP) has been suggested as a mechanism for lead-induced toxicity. The current study was carried out to evaluate antioxidant activity of hesperetin against lead acetate-induced oxidative stress. MATERIALS AND METHODS: The male rats were...

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Autores principales: Wang, Jicang, Zhu, Huali, Yang, Zijun, Liu, Zongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757611/
https://www.ncbi.nlm.nih.gov/pubmed/24014918
http://dx.doi.org/10.4103/0253-7613.115015
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author Wang, Jicang
Zhu, Huali
Yang, Zijun
Liu, Zongping
author_facet Wang, Jicang
Zhu, Huali
Yang, Zijun
Liu, Zongping
author_sort Wang, Jicang
collection PubMed
description OBJECTIVES: Oxidative stress with subsequent lipid peroxidation (LP) has been suggested as a mechanism for lead-induced toxicity. The current study was carried out to evaluate antioxidant activity of hesperetin against lead acetate-induced oxidative stress. MATERIALS AND METHODS: The male rats were treated with hesperetin in combination with lead acetate (500 mg/L). RESULTS: The results indicated that hesperetin alone did not induce any significant changes in the biochemistry of serum, liver, and kidney tissues. On the other hand, lead-induced oxidative stress as indicated by significant changes in serum biochemical parameters, including increased lipid peroxide and decreased reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels in liver and kidney tissues. Hesperetin succeeded in improving these biochemical parameters towards the normal values of control. CONCLUSIONS: It suggests that hesperetin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in liver and kidney of rats.
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spelling pubmed-37576112013-09-06 Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats Wang, Jicang Zhu, Huali Yang, Zijun Liu, Zongping Indian J Pharmacol Research Article OBJECTIVES: Oxidative stress with subsequent lipid peroxidation (LP) has been suggested as a mechanism for lead-induced toxicity. The current study was carried out to evaluate antioxidant activity of hesperetin against lead acetate-induced oxidative stress. MATERIALS AND METHODS: The male rats were treated with hesperetin in combination with lead acetate (500 mg/L). RESULTS: The results indicated that hesperetin alone did not induce any significant changes in the biochemistry of serum, liver, and kidney tissues. On the other hand, lead-induced oxidative stress as indicated by significant changes in serum biochemical parameters, including increased lipid peroxide and decreased reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels in liver and kidney tissues. Hesperetin succeeded in improving these biochemical parameters towards the normal values of control. CONCLUSIONS: It suggests that hesperetin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in liver and kidney of rats. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757611/ /pubmed/24014918 http://dx.doi.org/10.4103/0253-7613.115015 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Jicang
Zhu, Huali
Yang, Zijun
Liu, Zongping
Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats
title Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats
title_full Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats
title_fullStr Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats
title_full_unstemmed Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats
title_short Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats
title_sort antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757611/
https://www.ncbi.nlm.nih.gov/pubmed/24014918
http://dx.doi.org/10.4103/0253-7613.115015
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