Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats
OBJECTIVES: Oxidative stress with subsequent lipid peroxidation (LP) has been suggested as a mechanism for lead-induced toxicity. The current study was carried out to evaluate antioxidant activity of hesperetin against lead acetate-induced oxidative stress. MATERIALS AND METHODS: The male rats were...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757611/ https://www.ncbi.nlm.nih.gov/pubmed/24014918 http://dx.doi.org/10.4103/0253-7613.115015 |
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author | Wang, Jicang Zhu, Huali Yang, Zijun Liu, Zongping |
author_facet | Wang, Jicang Zhu, Huali Yang, Zijun Liu, Zongping |
author_sort | Wang, Jicang |
collection | PubMed |
description | OBJECTIVES: Oxidative stress with subsequent lipid peroxidation (LP) has been suggested as a mechanism for lead-induced toxicity. The current study was carried out to evaluate antioxidant activity of hesperetin against lead acetate-induced oxidative stress. MATERIALS AND METHODS: The male rats were treated with hesperetin in combination with lead acetate (500 mg/L). RESULTS: The results indicated that hesperetin alone did not induce any significant changes in the biochemistry of serum, liver, and kidney tissues. On the other hand, lead-induced oxidative stress as indicated by significant changes in serum biochemical parameters, including increased lipid peroxide and decreased reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels in liver and kidney tissues. Hesperetin succeeded in improving these biochemical parameters towards the normal values of control. CONCLUSIONS: It suggests that hesperetin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in liver and kidney of rats. |
format | Online Article Text |
id | pubmed-3757611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37576112013-09-06 Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats Wang, Jicang Zhu, Huali Yang, Zijun Liu, Zongping Indian J Pharmacol Research Article OBJECTIVES: Oxidative stress with subsequent lipid peroxidation (LP) has been suggested as a mechanism for lead-induced toxicity. The current study was carried out to evaluate antioxidant activity of hesperetin against lead acetate-induced oxidative stress. MATERIALS AND METHODS: The male rats were treated with hesperetin in combination with lead acetate (500 mg/L). RESULTS: The results indicated that hesperetin alone did not induce any significant changes in the biochemistry of serum, liver, and kidney tissues. On the other hand, lead-induced oxidative stress as indicated by significant changes in serum biochemical parameters, including increased lipid peroxide and decreased reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels in liver and kidney tissues. Hesperetin succeeded in improving these biochemical parameters towards the normal values of control. CONCLUSIONS: It suggests that hesperetin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in liver and kidney of rats. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3757611/ /pubmed/24014918 http://dx.doi.org/10.4103/0253-7613.115015 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Jicang Zhu, Huali Yang, Zijun Liu, Zongping Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats |
title | Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats |
title_full | Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats |
title_fullStr | Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats |
title_full_unstemmed | Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats |
title_short | Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats |
title_sort | antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757611/ https://www.ncbi.nlm.nih.gov/pubmed/24014918 http://dx.doi.org/10.4103/0253-7613.115015 |
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