New Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors

Objective(s): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards Fe(III)-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sul...

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Detalles Bibliográficos
Autores principales: Pooryaghoobi, Nona, Bakavoli, Mehdi, Alimardani, Maliheh, Bazzazan, Tahmineh, Sadeghian, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758034/
https://www.ncbi.nlm.nih.gov/pubmed/23997905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758034/
https://www.ncbi.nlm.nih.gov/pubmed/23997905

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