Force Spectroscopy Measurements Show That Cortical Neurons Exposed to Excitotoxic Agonists Stiffen before Showing Evidence of Bleb Damage

In ischemic and traumatic brain injury, hyperactivated glutamate (N-methyl-D-aspartic acid, NMDA) and sodium (Nav) channels trigger excitotoxic neuron death. Na(+), Ca(++) and H(2)O influx into affected neurons elicits swelling (increased cell volume) and pathological blebbing (disassociation of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Zou, Shan, Chisholm, Roderick, Tauskela, Joseph S., Mealing, Geoff A., Johnston, Linda J., Morris, Catherine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758302/
https://www.ncbi.nlm.nih.gov/pubmed/24023686
http://dx.doi.org/10.1371/journal.pone.0073499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758302/
https://www.ncbi.nlm.nih.gov/pubmed/24023686
http://dx.doi.org/10.1371/journal.pone.0073499

Ejemplares similares