Is Upregulation of BCL2 a Determinant of Tumor Development Driven by Inactivation of CDH1/E-Cadherin?

Inactivation of CDH1, encoding E-cadherin, promotes cancer initiation and progression. According to a newly proposed molecular mechanism, loss of E-cadherin triggers an upregulation of the anti-apoptotic oncoprotein BCL2. Conversely, reconstitution of E-cadherin counteracts overexpression of BCL2. T...

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Detalles Bibliográficos
Autores principales: Karch, Inga, Schipper, Elisa, Christgen, Henriette, Kreipe, Hans, Lehmann, Ulrich, Christgen, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758309/
https://www.ncbi.nlm.nih.gov/pubmed/24023670
http://dx.doi.org/10.1371/journal.pone.0073062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758309/
https://www.ncbi.nlm.nih.gov/pubmed/24023670
http://dx.doi.org/10.1371/journal.pone.0073062

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