Cargando…

Is Upregulation of BCL2 a Determinant of Tumor Development Driven by Inactivation of CDH1/E-Cadherin?

Inactivation of CDH1, encoding E-cadherin, promotes cancer initiation and progression. According to a newly proposed molecular mechanism, loss of E-cadherin triggers an upregulation of the anti-apoptotic oncoprotein BCL2. Conversely, reconstitution of E-cadherin counteracts overexpression of BCL2. T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karch, Inga, Schipper, Elisa, Christgen, Henriette, Kreipe, Hans, Lehmann, Ulrich, Christgen, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758309/ https://www.ncbi.nlm.nih.gov/pubmed/24023670 http://dx.doi.org/10.1371/journal.pone.0073062

Ejemplares similares

E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements
por: Christgen, Matthias, et al.
Publicado: (2020)

High frequency of lobular breast cancer in distant metastases to the orbit
por: Raap, Mieke, et al.
Publicado: (2015)

Reliable microRNA profiling in routinely processed formalin-fixed paraffin-embedded breast cancer specimens using fluorescence labelled bead technology
por: Hasemeier, Britta, et al.
Publicado: (2008)

Identification of differentially expressed microRNAs in human male breast cancer
por: Lehmann, Ulrich, et al.
Publicado: (2010)

Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma
por: Sflomos, George, et al.
Publicado: (2023)

Limited Value of KAI1/CD82 Protein Expression as a Prognostic Marker in Human Gastric Cancer
por: Knoener, Maximilian, et al.
Publicado: (2012)

Clinical validity and clinical utility of Ki67 in early breast cancer
por: Kreipe, Hans, et al.
Publicado: (2022)

Chromosome 2q gain and epigenetic silencing of GATA3 in microglandular adenosis of the breast
por: Radner, Martin, et al.
Publicado: (2020)

ERBB2 mutation is associated with sustained tumor cell proliferation after short-term preoperative endocrine therapy in early lobular breast cancer
por: Grote, Isabel, et al.
Publicado: (2022)

Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) Drives Proliferation of IPH-926 lobular Carcinoma Cells
por: van Agthoven, Ton, et al.
Publicado: (2015)

Frequent and Distinct Aberrations of DNA Methylation Patterns in Fibrolamellar Carcinoma of the Liver
por: Tränkenschuh, Wolfgang, et al.
Publicado: (2010)

Prognostic factors in the myoepithelial-like spindle cell type of metaplastic breast cancer
por: Leo, Fabian, et al.
Publicado: (2016)

Precise ERBB2 copy number assessment in breast cancer by means of molecular inversion probe array analysis
por: Christgen, Matthias, et al.
Publicado: (2016)

Comprehensive Molecular Profiling of Archival Bone Marrow Trephines Using a Commercially Available Leukemia Panel and Semiconductor-Based Targeted Resequencing
por: Bartels, Stephan, et al.
Publicado: (2015)

CDH1 (E-cadherin) Gene Methylation in Human Breast Cancer: Critical Appraisal of a Long and Twisted Story
por: Bücker, Lara, et al.
Publicado: (2022)

TP53 mutations are associated with primary endocrine resistance in luminal early breast cancer
por: Grote, Isabel, et al.
Publicado: (2021)

Co-expression of transcription factor AP-2beta (TFAP2B) and GATA3 in human mammary epithelial cells with intense, apicobasal immunoreactivity for CK8/18
por: Raap, M., et al.
Publicado: (2021)

Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors
por: Christgen, Matthias, et al.
Publicado: (2021)

Routine clinical mutation profiling using next generation sequencing and a customized gene panel improves diagnostic precision in myeloid neoplasms
por: Bartels, Stephan, et al.
Publicado: (2016)

Subclonal analysis in a lobular breast cancer with classical and solid growth pattern mimicking a solid‐papillary carcinoma
por: Christgen, Matthias, et al.
Publicado: (2017)

Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia
por: Balan, Shabeesh, et al.
Publicado: (2021)

Lobular breast cancer: molecular basis, mouse and cellular models
por: Christgen, Matthias, et al.
Publicado: (2015)

FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts
por: Black, Markaisa, et al.
Publicado: (2018)

3D Chromatin Architecture Re-Wiring at the CDH3/CDH1 Loci Contributes to E-Cadherin to P-Cadherin Expression Switch in Gastric Cancer
por: São José, Celina, et al.
Publicado: (2023)

LINE-1 hypomethylation in human hepatocellular carcinomas correlates with shorter overall survival and CIMP phenotype
por: Anwar, Sumadi Lukman, et al.
Publicado: (2019)

Cardiac Phlegmon: Infectious Endocarditis Causing Ventricular Wall Rupture
por: Fleißner, Felix, et al.
Publicado: (2020)

An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition
por: Ondracka, Andrej, et al.
Publicado: (2016)

Expression and Prognostic Significance of Cadherin 4 (CDH4) in Renal Cell Carcinoma
por: Zhou, Xiaohui, et al.
Publicado: (2020)

Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer
por: Ku, Su-Chi, et al.
Publicado: (2022)

CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer
por: Caldeira, José Roberto F, et al.
Publicado: (2006)

Role of the Adiponectin Binding Protein, T-Cadherin (Cdh13), in Allergic Airways Responses in Mice
por: Williams, Alison S., et al.
Publicado: (2012)

CDH3/P-Cadherin regulates migration of HuCCT1 cholangiocarcinoma cells
por: Baek, Sungmin, et al.
Publicado: (2010)

Role of the Adiponectin Binding Protein, T-Cadherin (cdh13), in Pulmonary Responses to Subacute Ozone
por: Kasahara, David I., et al.
Publicado: (2013)

Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity
por: Lachowicz-Scroggins, Marrah E., et al.
Publicado: (2018)

E-Cadherin (CDH1 Gene) Germline Mutations in Gastric Cancer: Evolutions and Innovations
por: Corso, Giovanni, et al.
Publicado: (2020)

Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia
por: Parker, Jessica, et al.
Publicado: (2023)

Loss of Imprinting and Allelic Switching at the DLK1-MEG3 Locus in Human Hepatocellular Carcinoma
por: Anwar, Sumadi Lukman, et al.
Publicado: (2012)

Loss of DNA methylation at imprinted loci is a frequent event in hepatocellular carcinoma and identifies patients with shortened survival
por: Anwar, Sumadi Lukman, et al.
Publicado: (2015)

Concordance in detection of microsatellite instability by PCR and NGS in routinely processed tumor specimens of several cancer types
por: Bartels, Stephan, et al.
Publicado: (2023)

Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface
por: Karthikeyan, Subbulakshmi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mpvpf8549do63jj85bivf98ql3