DNA methylation-mediated silencing of PU.1 in leukemia cells resistant to cell differentiation

In mice, the proviral integration of the Friend Spleen Focus Forming Virus (SFFV) within the PU.1 locus of erythroid precursors results in the development of erythroleukemia. SFFV integrates several kilobases upstream of the PU.1 transcription initiation start site leading to the constitutive activa...

Descripción completa

Detalles Bibliográficos
Autores principales: Fernández-Nestosa, María José, Monturus, Estefanía, Sánchez, Zunilda, Torres, Francisco S, Fernández, Agustín F, Fraga, Mario F, Hernández, Pablo, Schvartzman, Jorge B, Krimer, Dora B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758488/
https://www.ncbi.nlm.nih.gov/pubmed/24010046
http://dx.doi.org/10.1186/2193-1801-2-392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758488/
https://www.ncbi.nlm.nih.gov/pubmed/24010046
http://dx.doi.org/10.1186/2193-1801-2-392

Ejemplares similares