Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

Defining the relationship between ageing and cancer is a crucial but challenging task. Mice deficient in Zmpste24, a metalloproteinase mutated in human progeria and involved in nuclear prelamin A maturation, recapitulate multiple features of ageing. However, their short lifespan and serious cell-int...

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Detalles Bibliográficos
Autores principales: de la Rosa, Jorge, Freije, José M. P., Cabanillas, Rubén, Osorio, Fernando G., Fraga, Mario F., Fernández-García, M. Soledad, Rad, Roland, Fanjul, Víctor, Ugalde, Alejandro P., Liang, Qi, Prosser, Haydn M., Bradley, Allan, Cadiñanos, Juan, López-Otín, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758871/
https://www.ncbi.nlm.nih.gov/pubmed/23917225
http://dx.doi.org/10.1038/ncomms3268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758871/
https://www.ncbi.nlm.nih.gov/pubmed/23917225
http://dx.doi.org/10.1038/ncomms3268

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