Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells

Precise cellular targeting of macromolecular cargos has important biotechnological and medical implications. Using a recently established ‘protein stapling’ method, we linked the proteolytic domain of botulinum neurotoxin type A (BoNT/A) to a selection of ligands to target neuroendocrine tumor cells...

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Detalles Bibliográficos
Autores principales: Arsenault, Jason, Ferrari, Enrico, Niranjan, Dhevahi, Cuijpers, Sabine A G, Gu, Chunjing, Vallis, Yvonne, O'Brien, John, Davletov, Bazbek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758956/
https://www.ncbi.nlm.nih.gov/pubmed/23638840
http://dx.doi.org/10.1111/jnc.12284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758956/
https://www.ncbi.nlm.nih.gov/pubmed/23638840
http://dx.doi.org/10.1111/jnc.12284

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