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Combined effects of estrogen deficiency and cadmium exposure on calcified hard tissues: Animal model relating to itai-itai disease in postmenopausal women
Using ovariectomized rats as a model of postmenopausal women, we studied the effects of estrogen (Es) deficiency and in combination with cadmium (Cd) exposure on the calcified hard tissues related to the development of itai-itai disease. Es deficiency suppressed the synthesis of carbonic anhydrase r...
Autores principales: | KAKEI, Mitsuo, SAKAE, Toshiro, YOSHIKAWA, Masayoshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japan Academy
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758964/ https://www.ncbi.nlm.nih.gov/pubmed/23883612 http://dx.doi.org/10.2183/pjab.89.340 |
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