Cargando…

NMR spectroscopic detection of chirality and enantiopurity in referenced systems without formation of diastereomers

Enantiomeric excess of chiral compounds is a key parameter that determines their activity or therapeutic action. The current paradigm for rapid measurement of enantiomeric excess using NMR is based on the formation of diastereomeric complexes between the chiral analyte and a chiral resolving agent,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Labuta, Jan, Ishihara, Shinsuke, Šikorský, Tomáš, Futera, Zdeněk, Shundo, Atsuomi, Hanyková, Lenka, Burda, Jaroslav V., Ariga, Katsuhiko, Hill, Jonathan P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759048/ https://www.ncbi.nlm.nih.gov/pubmed/23864041 http://dx.doi.org/10.1038/ncomms3188

Ejemplares similares

Structural Modulation of Chromic Response: Effects of Binding‐Site Blocking in a Conjugated Calix[4]pyrrole Chromophore
por: Březina, Václav, et al.
Publicado: (2018)

HPLC Separation of Diastereomers: Chiral Molecular Tools Useful for the Preparation of Enantiopure Compounds and Simultaneous Determination of Their Absolute Configurations
por: Harada, Nobuyuki
Publicado: (2016)

Expedited Selection of NMR Chiral Solvating Agents for Determination of Enantiopurity
por: Yang, Lu, et al.
Publicado: (2016)

NMR lineshape analysis using analytical solutions of multi-state chemical exchange with applications to kinetics of host–guest systems
por: Březina, Václav, et al.
Publicado: (2022)

Chiral (1)H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
por: Wu, Chaofei, et al.
Publicado: (2018)

Poly(N,N′-Diethylacrylamide)-Based Thermoresponsive Hydrogels with Double Network Structure
por: Hanyková, Lenka, et al.
Publicado: (2020)

Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts
por: Ariga, Katsuhiko, et al.
Publicado: (2010)

Network Formation and Physical Properties of Epoxy Resins for Future Practical Applications
por: Shundo, Atsuomi, et al.
Publicado: (2022)

Development of highly potent chiral discrimination methods that solve the problems of the diastereomer method
por: Ohrui, Hiroshi
Publicado: (2007)

Excited States Symmetry Breaking and In-Plane Polarization Cause Chiral Reversal in Diastereomers
por: Wang, Chenglong, et al.
Publicado: (2021)

A simple protocol for determination of enantiopurity of amines using BINOL derivatives as chiral solvating agents via(1)H- and (19)F-NMR spectroscopic analysis
por: Chaudhary, Pooja, et al.
Publicado: (2022)

Improving the Colloidal Stability of Temperature-Sensitive Poly(N-isopropylacrylamide) Solutions Using Low Molecular Weight Hydrophobic Additives
por: Velychkivska, Nadiia, et al.
Publicado: (2018)

Antifreeze glycopeptide diastereomers
por: Nagel, Lilly, et al.
Publicado: (2012)

Production of Enantiopure Chiral Epoxides with E. coli Expressing Styrene Monooxygenase
por: Gyuranová, Dominika, et al.
Publicado: (2021)

Multimodal switching of a redox-active macrocycle
por: Payne, Daniel T., et al.
Publicado: (2019)

Low-Energy Collisions of Protonated Enantiopure Amino Acids with Chiral Target Gases
por: Kulyk, K., et al.
Publicado: (2017)

Enantiopure Chiral Coordination Polymers Based on Polynuclear Paddlewheel Helices and Arsenyl Tartrate
por: Valentín-Pérez, Ángela, et al.
Publicado: (2018)

Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters
por: Benedetti, Fabio, et al.
Publicado: (2016)

Synthesis and characterization of enantiopure planar–chiral phosphorus-linked diferrocenes
por: Honegger, Philipp, et al.
Publicado: (2021)

Applied Circular Dichroism: A Facile Spectroscopic Tool for Configurational Assignment and Determination of Enantiopurity
por: Okuom, Macduff O., et al.
Publicado: (2015)

Application of NMR Spectroscopy for the Detection of Equilibrating E–Z Diastereomers
por: Hussaini, Syed Raziullah, et al.
Publicado: (2020)

Deracemization of Axially Chiral Nicotinamides by Dynamic Salt Formation with Enantiopure Dibenzoyltartaric Acid (DBTA)
por: Yagishita, Fumitoshi, et al.
Publicado: (2013)

A Triptycene‐Based Enantiopure Bis(Diazadibenzoanthracene) by a Chirality‐Assisted Synthesis Approach
por: Wang, Xubin, et al.
Publicado: (2020)

Enantiopure polythiophene nanoparticles. Chirality dependence of cellular uptake, intracellular distribution and antimicrobial activity
por: Palamà, Ilaria Elena, et al.
Publicado: (2019)

Preparation of chiral 3-oxocycloalkanecarbonitrile and its derivatives by crystallization-induced diastereomer transformation of ketals with chiral 1,2-diphenylethane-1,2-diol
por: Yamashita, Yohei, et al.
Publicado: (2018)

Dissymmetry Factor Spectral Analysis Can Provide Useful Diastereomer Discrimination: Chiral Molecular Structure of an Analogue of (−)-Crispine A
por: Johnson, Jordan L., et al.
Publicado: (2019)

Optical Resolution of Carboxylic Acid Derivatives of Homoleptic Cyclometalated Iridium(III) Complexes via Diastereomers Formed with Chiral Auxiliaries
por: Kanbe, Azusa, et al.
Publicado: (2023)

Correction to “Optical Resolution of Carboxylic Acid Derivatives of Homoleptic Cyclometalated Iridium(III) Complexes via Diastereomers Formed with Chiral Auxiliaries”
por: Kanbe, Azusa, et al.
Publicado: (2023)

Directing Intrinsic Chirality in Gold Nanoclusters: Preferential Formation of Stable Enantiopure Clusters in High Yield and Experimentally Unveiling the “Super” Chirality of Au(144)
por: Truttmann, Vera, et al.
Publicado: (2023)

Investigation of factors influencing the separation of diastereomers of phosphorothioated oligonucleotides
por: Enmark, Martin, et al.
Publicado: (2019)

Total Synthesis of (+)-Petromyroxol, (−)-iso-Petromyroxol, and Possible Diastereomers
por: Mullapudi, Venkannababu, et al.
Publicado: (2020)

Enantiopure nanohoops through racemic resolution of diketo[n]CPPs by chiral derivatization as precursors to DBP[n]CPPs
por: Wassy, Daniel, et al.
Publicado: (2021)

Insights into Mechanical Dynamics of Nanoscale Interfaces in Epoxy Composites Using Nanorheology Atomic Force Microscopy
por: Nguyen, Hung K., et al.
Publicado: (2023)

Structure of Plasma (re)Polymerized Polylactic Acid Films Fabricated by Plasma-Assisted Vapour Thermal Deposition
por: Krtouš, Zdeněk, et al.
Publicado: (2021)

Enantiopure Derivatives of Aza-Baylis-Hillman Adducts by Subsequent S(N)′-S(N)′ Reactions of Acylcarbamates Bearing a Chiral Auxiliary
por: Martelli, Gianluca, et al.
Publicado: (2009)

Novel Enantiopure Sigma Receptor Modulators: Quick (Semi-)Preparative Chiral Resolution via HPLC and Absolute Configuration Assignment
por: Rui, Marta, et al.
Publicado: (2016)

The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers
por: Szpera, Robert, et al.
Publicado: (2017)

The Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review
por: Karunakaran, Thiruventhan, et al.
Publicado: (2022)

One-pot tandem cyclization of enantiopure asymmetric cis-2,5-disubstituted pyrrolidines: Facile access to chiral 10-heteroazatriquinanes
por: Wang, Ping-An, et al.
Publicado: (2013)

Organocatalytic Michael Addition to (D)-Mannitol-Derived Enantiopure Nitroalkenes: A Valuable Strategy for the Synthesis of Densely Functionalized Chiral Molecules
por: Caruso, Lucia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_a06lf49m0i0q45l3divlki8ovu