p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1

The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell line HCT116, which lacks p53 exhibits significantly lower major histocompatibility complex I expression...

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Detalles Bibliográficos
Autores principales: Wang, Bei, Niu, Dandan, Lai, Liyun, Ren, Ee Chee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759077/
https://www.ncbi.nlm.nih.gov/pubmed/23965983
http://dx.doi.org/10.1038/ncomms3359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759077/
https://www.ncbi.nlm.nih.gov/pubmed/23965983
http://dx.doi.org/10.1038/ncomms3359

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