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p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1
The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell line HCT116, which lacks p53 exhibits significantly lower major histocompatibility complex I expression...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759077/ https://www.ncbi.nlm.nih.gov/pubmed/23965983 http://dx.doi.org/10.1038/ncomms3359 |