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A Mechanistic Model for Amorphous Protein Aggregation of Immunoglobulin-like Domains

[Image: see text] Protein aggregation is associated with many debilitating diseases including Alzheimer’s, Parkinson’s, and light-chain amyloidosis (AL). Additionally, such aggregation is a major problem in an industrial setting where antibody therapeutics often require high local concentrations of...

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Detalles Bibliográficos
Autores principales: Borgia, Madeleine B., Nickson, Adrian A., Clarke, Jane, Hounslow, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759167/
https://www.ncbi.nlm.nih.gov/pubmed/23510407
http://dx.doi.org/10.1021/ja308852b