Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models

Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidity, and is caused by mutations in either of two genes, TSC1 or TSC2. Most affected individuals display severe neurological manifestations – such as intractable epilepsy, mental retardation and autism –...

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Detalles Bibliográficos
Autores principales: Magri, Laura, Cominelli, Manuela, Cambiaghi, Marco, Cursi, Marco, Leocani, Letizia, Minicucci, Fabio, Poliani, Pietro Luigi, Galli, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759338/
https://www.ncbi.nlm.nih.gov/pubmed/23744272
http://dx.doi.org/10.1242/dmm.012096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759338/
https://www.ncbi.nlm.nih.gov/pubmed/23744272
http://dx.doi.org/10.1242/dmm.012096

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