Distal Effect of Amino Acid Substitutions in CYP2C9 Polymorphic Variants Causes Differences in Interatomic Interactions against (S)-Warfarin

Cytochrome P450 2C9 (CYP2C9) is crucial in excretion of commonly prescribed drugs. However, changes in metabolic activity caused by CYP2C9 polymorphisms inevitably result in adverse drug effects. CYP2C9*2 and *3 are prevalent in Caucasian populations whereas CYP2C9*13 is remarkable in Asian populati...

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Detalles Bibliográficos
Autores principales: Lertkiatmongkol, Panida, Assawamakin, Anunchai, White, George, Chopra, Gaurav, Rongnoparut, Pornpimol, Samudrala, Ram, Tongsima, Sissades
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759441/
https://www.ncbi.nlm.nih.gov/pubmed/24023924
http://dx.doi.org/10.1371/journal.pone.0074053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759441/
https://www.ncbi.nlm.nih.gov/pubmed/24023924
http://dx.doi.org/10.1371/journal.pone.0074053

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