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Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
Senescence is a stable proliferation arrest, associated with an altered secretory pathway, thought to promote tumor suppression and tissue aging. While chromatin regulation and lamin B1 down-regulation have been implicated as senescence effectors, functional interactions between them are poorly unde...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759695/ https://www.ncbi.nlm.nih.gov/pubmed/23934658 http://dx.doi.org/10.1101/gad.223834.113 |