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Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence

Senescence is a stress-responsive form of stable cell cycle exit. Senescent cells have a distinct gene expression profile, which is often accompanied by the spatial redistribution of heterochromatin into senescence-associated heterochromatic foci (SAHFs). Studying a key component of the nuclear lami...

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Detalles Bibliográficos
Autores principales: Sadaie, Mahito, Salama, Rafik, Carroll, Thomas, Tomimatsu, Kosuke, Chandra, Tamir, Young, Andrew R.J., Narita, Masako, Pérez-Mancera, Pedro A., Bennett, Dorothy C., Chong, Heung, Kimura, Hiroshi, Narita, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759696/
https://www.ncbi.nlm.nih.gov/pubmed/23964094
http://dx.doi.org/10.1101/gad.217281.113