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Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase
Bloom syndrome, an autosomal recessive disorder of the BLM gene, confers predisposition to a broad spectrum of early-onset cancers in multiple tissue types. Loss of genomic integrity is a primary hallmark of such human malignancies, but many studies using disease-affected specimens are limited in th...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759722/ https://www.ncbi.nlm.nih.gov/pubmed/23908384 http://dx.doi.org/10.1101/gr.152744.112 |