Matrine Activates PTEN to Induce Growth Inhibition and Apoptosis in (V600E)BRAF Harboring Melanoma Cells

Here, we report a natural chemical Matrine, which exhibits anti-melanoma potential with its PTEN activation mechanism. Matrine effectively inhibited proliferation of several carcinoma cell lines, including melanoma (V600E)BRAF harboring M21 cells. Flow cytometry analysis showed Matrine induced G(0)/...

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Detalles Bibliográficos
Autores principales: Jin, Hui, Sun, Yu, Wang, Shuiying, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759898/
https://www.ncbi.nlm.nih.gov/pubmed/23912239
http://dx.doi.org/10.3390/ijms140816040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759898/
https://www.ncbi.nlm.nih.gov/pubmed/23912239
http://dx.doi.org/10.3390/ijms140816040

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