Cargando…

pH-Triggered Conformational Switching along the Membrane Insertion Pathway of the Diphtheria Toxin T-Domain

The translocation (T)-domain plays a key role in the action of diphtheria toxin and is responsible for transferring the catalytic domain across the endosomal membrane into the cytosol in response to acidification. Deciphering the molecular mechanism of pH-dependent refolding and membrane insertion o...

Descripción completa

Detalles Bibliográficos
Autor principal: Ladokhin, Alexey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760040/
https://www.ncbi.nlm.nih.gov/pubmed/23925141
http://dx.doi.org/10.3390/toxins5081362