Cargando…

Earthworm-Derived Pore-Forming Toxin Lysenin and Screening of Its Inhibitors

Lysenin is a pore-forming toxin from the coelomic fluid of earthworm Eisenia foetida. This protein specifically binds to sphingomyelin and induces erythrocyte lysis. Lysenin consists of 297 amino acids with a molecular weight of 41 kDa. We screened for cellular signal transduction inhibitors of low...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sukumwang, Neelanun, Umezawa, Kazuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760042/ https://www.ncbi.nlm.nih.gov/pubmed/23965430 http://dx.doi.org/10.3390/toxins5081392

Ejemplares similares

Insights into the Voltage Regulation Mechanism of the Pore-Forming Toxin Lysenin
por: Bryant, Sheenah Lynn, et al.
Publicado: (2018)

Temporary Membrane Permeabilization via the Pore-Forming Toxin Lysenin
por: Shrestha, Nisha, et al.
Publicado: (2020)

Structures of Lysenin Reveal a Shared Evolutionary Origin for Pore-Forming Proteins And Its Mode of Sphingomyelin Recognition
por: De Colibus, Luigi, et al.
Publicado: (2012)

Lysenin Channels as Sensors for Ions and Molecules
por: Bogard, Andrew, et al.
Publicado: (2020)

Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein
por: Bokori-Brown, Monika, et al.
Publicado: (2016)

Bacterial pore-forming toxins
por: Ulhuq, Fatima R., et al.
Publicado: (2022)

Insight into the Structural Dynamics of the Lysenin During Prepore-to-Pore Transition Using Hydrogen–Deuterium Exchange Mass Spectrometry
por: Kulma, Magdalena, et al.
Publicado: (2019)

Cationic Polymers Inhibit the Conductance of Lysenin Channels
por: Fologea, Daniel, et al.
Publicado: (2013)

Stochastic sensing of Angiotensin II with lysenin channels
por: Shrestha, Nisha, et al.
Publicado: (2017)

Role of Pore-Forming Toxins in Neonatal Sepsis
por: Sonnen, Andreas F.-P., et al.
Publicado: (2013)

Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?
por: Ostolaza, Helena, et al.
Publicado: (2019)

Structural Basis of the Pore-Forming Toxin/Membrane Interaction
por: Li, Yajuan, et al.
Publicado: (2021)

The MACPF/CDC family of pore-forming toxins
por: Rosado, Carlos J, et al.
Publicado: (2008)

The Ionic Selectivity of Lysenin Channels in Open and Sub-Conducting States
por: Bogard, Andrew, et al.
Publicado: (2021)

Liposomes Prevent In Vitro Hemolysis Induced by Streptolysin O and Lysenin
por: Ayllon, Marcelo, et al.
Publicado: (2021)

Staphylococcal Bicomponent Pore-Forming Toxins: Targets for Prophylaxis and Immunotherapy
por: Aman, M. Javad, et al.
Publicado: (2014)

Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins
por: Etxaniz, Asier, et al.
Publicado: (2018)

Response of Cellular Innate Immunity to Cnidarian Pore-Forming Toxins
por: Yap, Wei Yuen, et al.
Publicado: (2018)

Membrane perforation by the pore-forming toxin pneumolysin
por: Vögele, Martin, et al.
Publicado: (2019)

An Effective Electric Dipole Model for Voltage-induced Gating Mechanism of Lysenin
por: Faouri, Radwan Al, et al.
Publicado: (2019)

Modulation of Voltage-Gating and Hysteresis of Lysenin Channels by Cu(2+) Ions
por: Bogard, Andrew, et al.
Publicado: (2023)

Mechanisms protecting host cells against bacterial pore-forming toxins
por: Brito, Cláudia, et al.
Publicado: (2018)

Functional Consequences of Calcium Influx Promoted by Bacterial Pore-Forming Toxins
por: Bouillot, Stéphanie, et al.
Publicado: (2018)

Human Monocyte-Derived Osteoclasts Are Targeted by Staphylococcal Pore-Forming Toxins and Superantigens
por: Flammier, Sacha, et al.
Publicado: (2016)

Structural and Mechanistic Features of ClyA-Like α-Pore-Forming Toxins
por: Bräuning, Bastian, et al.
Publicado: (2018)

Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection
por: Escajadillo, Tamara, et al.
Publicado: (2018)

ZnO nanoparticles modulate the ionic transport and voltage regulation of lysenin nanochannels
por: Bryant, Sheenah L., et al.
Publicado: (2017)

A biomimetic nanosponge that absorbs pore-forming toxins
por: Hu, Che-Ming J., et al.
Publicado: (2013)

Cellular Entry of Binary and Pore-Forming Bacterial Toxins
por: Ladokhin, Alexey S.
Publicado: (2017)

Pore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets
por: Hu, Haijie, et al.
Publicado: (2021)

Single channel properties of lysenin measured in artificial lipid bilayers and their applications to biomolecule detection
por: AOKI, Takaaki, et al.
Publicado: (2010)

Pro-autophagic signal induction by bacterial pore-forming toxins
por: Kloft, Nicole, et al.
Publicado: (2010)

Global Functional Analyses of Cellular Responses to Pore-Forming Toxins
por: Kao, Cheng-Yuan, et al.
Publicado: (2011)

Disarming Pore-Forming Toxins with Biomimetic Nanosponges in Intraocular Infections
por: Coburn, Phillip S., et al.
Publicado: (2019)

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins
por: Ormsby, Thomas J. R., et al.
Publicado: (2022)

The Importance of Pore-Forming Toxins in Multiple Organ Injury and Dysfunction
por: Abrams, Simon T., et al.
Publicado: (2022)

Curcumin Inhibits Membrane-Damaging Pore-Forming Function of the β-Barrel Pore-Forming Toxin Vibrio cholerae Cytolysin
por: Singh, Mahendra, et al.
Publicado: (2022)

Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms
por: Wang, Liyan, et al.
Publicado: (2021)

Toxicological and biochemical responses of the earthworm Eisenia fetida to cyanobacteria toxins
por: Cao, Qing, et al.
Publicado: (2017)

NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens
por: Keyburn, Anthony L., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_kisafaug3tbkpl929qf959hdrp