ABCB1 haplotypes do not influence transport or efficacy of tyrosine kinase inhibitors in vitro

Single-nucleotide polymorphisms (SNPs) in the gene coding for the efflux-transport protein ABCB1 (P-glycoprotein) are commonly inherited as haplotypes. ABCB1 SNPs and haplotypes have been suggested to influence the pharmacokinetics and therapeutic outcome of the tyrosine kinase inhibitor (TKI) imati...

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Detalles Bibliográficos
Autores principales: Skoglund, Karin, Moreno, Samuel Boiso, Baytar, Maria, Jönsson, Jan-Ingvar, Gréen, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760445/
https://www.ncbi.nlm.nih.gov/pubmed/24019750
http://dx.doi.org/10.2147/PGPM.S45522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760445/
https://www.ncbi.nlm.nih.gov/pubmed/24019750
http://dx.doi.org/10.2147/PGPM.S45522

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