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Adaptation to the spindle checkpoint is regulated by the interplay between Cdc28/Clbs and PP2A(Cdc55)

The spindle checkpoint arrests cells in metaphase until all chromosomes are properly attached to the chromosome segregation machinery. Thereafter, the anaphase promoting complex (APC/C) is activated and chromosome segregation can take place. Cells remain arrested in mitosis for hours in response to...

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Detalles Bibliográficos
Autores principales: Vernieri, Claudio, Chiroli, Elena, Francia, Valentina, Gross, Fridolin, Ciliberto, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760609/
https://www.ncbi.nlm.nih.gov/pubmed/23999167
http://dx.doi.org/10.1083/jcb.201303033