JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

Neurons are highly polarized cells that often project axons a considerable distance. To respond to axonal damage, neurons must transmit a retrograde signal to the nucleus to enable a transcriptional stress response. Here we describe a mechanism by which this signal is propagated through injury-induc...

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Detalles Bibliográficos
Autores principales: Huntwork-Rodriguez, Sarah, Wang, Bei, Watkins, Trent, Ghosh, Arundhati Sengupta, Pozniak, Christine D., Bustos, Daisy, Newton, Kim, Kirkpatrick, Donald S., Lewcock, Joseph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760612/
https://www.ncbi.nlm.nih.gov/pubmed/23979718
http://dx.doi.org/10.1083/jcb.201303066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760612/
https://www.ncbi.nlm.nih.gov/pubmed/23979718
http://dx.doi.org/10.1083/jcb.201303066

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