Automated identification of functional dynamic networks from X-ray crystallography

Protein function often depends on the exchange between conformational substates. Allosteric ligand binding or distal mutations can stabilize specific active site conformations and consequently alter protein function. In addition to comparing independently determined X-ray crystal structures, alterna...

Descripción completa

Detalles Bibliográficos
Autores principales: van den Bedem, Henry, Bhabha, Gira, Yang, Kun, Wright, Peter E., Fraser, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760795/
https://www.ncbi.nlm.nih.gov/pubmed/23913260
http://dx.doi.org/10.1038/nmeth.2592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760795/
https://www.ncbi.nlm.nih.gov/pubmed/23913260
http://dx.doi.org/10.1038/nmeth.2592

Ejemplares similares