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Automated identification of functional dynamic networks from X-ray crystallography
Protein function often depends on the exchange between conformational substates. Allosteric ligand binding or distal mutations can stabilize specific active site conformations and consequently alter protein function. In addition to comparing independently determined X-ray crystal structures, alterna...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760795/ https://www.ncbi.nlm.nih.gov/pubmed/23913260 http://dx.doi.org/10.1038/nmeth.2592 |