Gli activation by aPKC iota/lambda regulates basal cell carcinoma growth

Basal cell carcinoma (BCC) growth requires high levels of Hedgehog (Hh) signaling through the transcription factor Gli(1). While inhibitors of membrane protein Smoothened (Smo) effectively suppress Hh signaling, early tumor resistance illustrates the need for additional downstream targets for therap...

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Detalles Bibliográficos
Autores principales: Atwood, Scott X., Li, Mischa, Lee, Alex, Tang, Jean Y., Oro, Anthony E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761364/
https://www.ncbi.nlm.nih.gov/pubmed/23446420
http://dx.doi.org/10.1038/nature11889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761364/
https://www.ncbi.nlm.nih.gov/pubmed/23446420
http://dx.doi.org/10.1038/nature11889

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