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A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery
A Multilayered Multidisk Tablet (MLMDT) comprising two drug-loaded disks enveloped by three drug-free barrier layers was developed for use in chronotherapeutic disorders, employing two model drugs, theophylline and diltiazem HCl. The MLMDT was designed to achieve two pulses of drug release separated...
Autores principales: | Khan, Zaheeda, Choonara, Yahya E., Kumar, Pradeep, du Toit, Lisa C., Ndesendo, Valence M. K., Pillay, Viness |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762207/ https://www.ncbi.nlm.nih.gov/pubmed/24024200 http://dx.doi.org/10.1155/2013/569470 |
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