Cargando…

Zanamivir Oral Delivery: Enhanced Plasma and Lung Bioavailability in Rats

The objective of this study was to enhance the oral bioavailability (BA) of zanamivir (ZMR) by increasing its intestinal permeability using permeation enhancers (PE). Four different classes of PEs (Labrasol(®), sodium cholate, sodium caprate, hydroxypropyl β-cyclodextrin) were investigated for their...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shanmugam, Srinivasan, Im, Ho Taek, Sohn, Young Taek, Kim, Kyung Soo, Kim, Yong- Il, Yong, Chul Soon, Kim, Jong Oh, Choi, Han-Gon, Woo, Jong Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Applied Pharmacology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762309/ https://www.ncbi.nlm.nih.gov/pubmed/24009875 http://dx.doi.org/10.4062/biomolther.2013.010

Ejemplares similares

A novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for improved stability and oral bioavailability of an oily drug, 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol
por: Kim, Kyeong Soo, et al.
Publicado: (2017)

Comparison of 1-Palmitoyl-2-Linoleoyl-3-Acetyl-Rac-Glycerol-Loaded Self-Emulsifying Granule and Solid Self-Nanoemulsifying Drug Delivery System: Powder Property, Dissolution and Oral Bioavailability
por: Kim, Dong Shik, et al.
Publicado: (2019)

Comparison of Three Different Aqueous Microenvironments for Enhancing Oral Bioavailability of Sildenafil: Solid Self-Nanoemulsifying Drug Delivery System, Amorphous Microspheres and Crystalline Microspheres
por: Kim, Jung Suk, et al.
Publicado: (2021)

Permeability Enhancers Dramatically Increase Zanamivir Absolute Bioavailability in Rats: Implications for an Orally Bioavailable Influenza Treatment
por: Holmes, Eric H., et al.
Publicado: (2013)

Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation
por: Yousaf, Abid Mehmood, et al.
Publicado: (2015)

Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate
por: Yousaf, Abid Mehmood, et al.
Publicado: (2016)

Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe
por: Rashid, Rehmana, et al.
Publicado: (2015)

Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives
por: Hong, Soon-Seok, et al.
Publicado: (2019)

Transferrin-Conjugated Polymeric Nanoparticle for Receptor-Mediated Delivery of Doxorubicin in Doxorubicin-Resistant Breast Cancer Cells
por: Soe, Zar Chi, et al.
Publicado: (2019)

Zanamivir should be inhaled, not nebulised
por: Eagel, Barry A
Publicado: (2010)

Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system
por: Yeom, Dong Woo, et al.
Publicado: (2017)

Solid formulation of a supersaturable self-microemulsifying drug delivery system for valsartan with improved dissolution and bioavailability
por: Yeom, Dong Woo, et al.
Publicado: (2017)

Efficacy and Safety Study of Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide Combination Therapy in Patients with Hypertension Not Controlled with Olmesartan Medoxomil and Hydrochlorothiazide Combination Therapy: Results of a Randomized, Double-Blind, Multicenter Trial
por: Sohn, Il Suk, et al.
Publicado: (2015)

Erratum to: Efficacy and Safety Study of Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide Combination Therapy in Patients with Hypertension Not Controlled with Olmesartan Medoxomil and Hydrochlorothiazide Combination Therapy: Results of a Randomized, Double-Blind, Multicenter Trial
por: Sohn, Il Suk, et al.
Publicado: (2016)

Intravenous zanamivir for influenza myocarditis and enteral malabsorption
por: Jahns, Fritz-Patrick, et al.
Publicado: (2018)

Serum IgE Levels in Korean Patients with Human Immunodeficiency Virus Infection
por: Park, Jee Hyun, et al.
Publicado: (2002)

Development of RP-HPLC method for simultaneous determination of docetaxel and curcumin in rat plasma: Validation and stability
por: Kim, Dong Wuk, et al.
Publicado: (2017)

A comparison of the influence of 2.7% sorbitol-0.54% mannitol and 5% glucose irrigating fluids on plasma serum physiology during hysteroscopic procedures
por: Park, Jong Taek, et al.
Publicado: (2011)

Whole genome sequencing of Nontuberculous Mycobacterium (NTM) isolates from sputum specimens of co-habiting patients with NTM pulmonary disease and NTM isolates from their environment
por: Yoon, Jung-Ki, et al.
Publicado: (2020)

Progressive slowdown/prevention of cellular senescence by CD9-targeted delivery of rapamycin using lactose-wrapped calcium carbonate nanoparticles
por: Thapa, Raj Kumar, et al.
Publicado: (2017)

Efficacy and Safety of Lobeglitazone Monotherapy in Patients with Type 2 Diabetes Mellitus over 24-Weeks: A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo Controlled Trial
por: Kim, Sin Gon, et al.
Publicado: (2014)

Neuraminidase Inhibitor Zanamivir Ameliorates Collagen-Induced Arthritis
por: Sehnert, Bettina, et al.
Publicado: (2021)

Comparison between simultaneous bilateral total hip arthroplasty with and without drainage: A retrospective cohort study
por: Kim, Min-Gwang, et al.
Publicado: (2022)

Irinotecan-encapsulated double-reverse thermosensitive nanocarrier system for rectal administration
por: Din, Fakhar ud, et al.
Publicado: (2017)

Coronary Heart Disease in Moyamoya Disease: Are They Concomitant or Coincidence?
por: Nam, Taek Min, et al.
Publicado: (2015)

Decreased Plasma BDNF Levels of Patients with Somatization Disorder
por: Kang, Nam-In, et al.
Publicado: (2016)

Emphysematous prostatic abscess due to Klebsiella pneumoniae: report of a case and review of the literature.
por: Bae, Gi-Bum, et al.
Publicado: (2003)

The prevalence of anemia and iron depletion in the population aged 10 years or older
por: Kim, Soon Ki, et al.
Publicado: (2011)

Return to Sports Activity After Reverse Total Shoulder Arthroplasty
por: Kim, Hyun Gon, et al.
Publicado: (2023)

A Study of Micronucleus Induction with Methyl Formate and 2-Methylbutane in Bone Marrow Cells of Male ICR Mice
por: Kim, Soo-Jin, et al.
Publicado: (2010)

Self-microemulsifying drug delivery system (SMEDDS) for improved oral delivery and photostability of methotrexate
por: Kim, Dong Shik, et al.
Publicado: (2019)

Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium
por: Giri, Bhupendra Raj, et al.
Publicado: (2021)

Comparison of efficacy and safety of oseltamivir and zanamivir in pandemic influenza treatment
por: Tuna, Nazan, et al.
Publicado: (2012)

Lessons from resistance analysis in clinical trials of IV zanamivir
por: Yates, Phillip J, et al.
Publicado: (2023)

Cerebral Coenurosis of a Long-Tailed Goral, Naemorhedus caudatus, in Korea
por: Ahn, Sangjin, et al.
Publicado: (2021)

Self-microemulsifying drug-delivery system for improved oral bioavailability of pranlukast hemihydrate: preparation and evaluation
por: Baek, Myoung-Ki, et al.
Publicado: (2013)

Clinical Application of Botulinum Toxin A for Calf Hypertrophy Followed by 3-Dimensional Computed Tomography
por: Oh, Won Jong, et al.
Publicado: (2018)

Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability, Photostability, and Permeability
por: Giri, Bhupendra Raj, et al.
Publicado: (2022)

Micro-/nano-sized delivery systems of ginsenosides for improved systemic bioavailability
por: Kim, Hyeongmin, et al.
Publicado: (2018)

Evaluation of the Genetic Toxicity of Cyclopentane and Ammonium Nitrate - In vitro Mammalian Chromosomal Aberration Assay in Chinese Hamster Ovary Cells
por: Kim, Soo-Jin, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_et4kemnme98kicgetaenqaeflo