AID stabilizes stem cell phenotype by removing epigenetic memory of pluripotency genes

The activation-induced cytidine deaminase enzyme (AID) is required for somatic hyper-mutation and class switch recombination at the immunoglobulin locus(1). In GC-B cells, AID is highly expressed, with inherent mutator activity that helps generate antibody diversity(2). However, AID may also regulat...

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Detalles Bibliográficos
Autores principales: Kumar, Ritu, DiMenna, Lauren, Schrode, Nadine, Liu, Ting-Chun, Franck, Philipp, Muñoz-Descalzo, Silvia, Hadjantonakis, Anna-Katerina, Zarrin, Ali A., Chaudhuri, Jayanta, Elemento, Olivier, Evans, Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762466/
https://www.ncbi.nlm.nih.gov/pubmed/23803762
http://dx.doi.org/10.1038/nature12299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762466/
https://www.ncbi.nlm.nih.gov/pubmed/23803762
http://dx.doi.org/10.1038/nature12299

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