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AID stabilizes stem cell phenotype by removing epigenetic memory of pluripotency genes
The activation-induced cytidine deaminase enzyme (AID) is required for somatic hyper-mutation and class switch recombination at the immunoglobulin locus(1). In GC-B cells, AID is highly expressed, with inherent mutator activity that helps generate antibody diversity(2). However, AID may also regulat...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762466/ https://www.ncbi.nlm.nih.gov/pubmed/23803762 http://dx.doi.org/10.1038/nature12299 |