The Chicken HS4 Insulator Element Does Not Protect the H19 ICR from Differential DNA Methylation in Yeast Artificial Chromosome Transgenic Mouse

Mono-allelic expression at the mouse IGF2/H19 locus is controlled by differential allelic DNA methylation of the imprinting control region (ICR). Because a randomly integrated H19 ICR fragment, when incorporated into the genome of transgenic mice (TgM), was allele-specifically methylated in somatic,...

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Detalles Bibliográficos
Autores principales: Okamura, Eiichi, Matsuzaki, Hitomi, Fukamizu, Akiyoshi, Tanimoto, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762768/
https://www.ncbi.nlm.nih.gov/pubmed/24023912
http://dx.doi.org/10.1371/journal.pone.0073925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762768/
https://www.ncbi.nlm.nih.gov/pubmed/24023912
http://dx.doi.org/10.1371/journal.pone.0073925

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