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Small Molecule Suppressors of Drosophila Kinesin Deficiency Rescue Motor Axon Development in a Zebrafish Model of Spinal Muscular Atrophy
Proximal spinal muscular atrophy (SMA) is the most common inherited motor neuropathy and the leading hereditary cause of infant mortality. Currently there is no effective treatment for the disease, reflecting a need for pharmacologic interventions that restore performance of dysfunctional motor neur...
Autores principales: | Gassman, Andrew, Hao, Le T., Bhoite, Leena, Bradford, Chad L., Chien, Chi-Bin, Beattie, Christine E., Manfredi, John P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762770/ https://www.ncbi.nlm.nih.gov/pubmed/24023935 http://dx.doi.org/10.1371/journal.pone.0074325 |
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