Cargando…

DYRK2 Negatively Regulates Cardiomyocyte Growth by Mediating Repressor Function of GSK-3β on eIF2Bε

BACKGROUND: A prerequisite of hypertrophic response of the myocardium is an increase in protein synthesis. A central regulator of translation initiation is Eukaryotic initiation factor 2B (eIF2B). Here we assessed the hypothesis that regulation of protein synthesis via eIF2Bε is essential to cardiac...

Descripción completa

Detalles Bibliográficos
Autores principales: Weiss, Celine S., Ochs, Marco M., Hagenmueller, Marco, Streit, Marcus R., Malekar, Pratima, Riffel, Johannes H., Buss, Sebastian J., Weiss, Karl H., Sadoshima, Junichi, Katus, Hugo A., Hardt, Stefan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762802/
https://www.ncbi.nlm.nih.gov/pubmed/24023715
http://dx.doi.org/10.1371/journal.pone.0070848