Downregulation of NOX4 Expression by Roflumilast N-Oxide Reduces Markers of Fibrosis in Lung Fibroblasts

The phosphodiesterase 4 inhibitor roflumilast prevents bleomycin- (BLM-) induced lung fibrosis in animal models. However, its mechanism of action remains unknown. We investigated whether roflumilast N-oxide (RNO), the active metabolite of roflumilast, can modulate in vitro the oxidative effects of B...

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Detalles Bibliográficos
Autores principales: Vecchio, Daniela, Acquaviva, Alessandra, Arezzini, Beatrice, Tenor, Hermann, Martorana, Piero A., Gardi, Concetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763264/
https://www.ncbi.nlm.nih.gov/pubmed/24027357
http://dx.doi.org/10.1155/2013/745984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763264/
https://www.ncbi.nlm.nih.gov/pubmed/24027357
http://dx.doi.org/10.1155/2013/745984

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