Cargando…

Downregulation of NOX4 Expression by Roflumilast N-Oxide Reduces Markers of Fibrosis in Lung Fibroblasts

The phosphodiesterase 4 inhibitor roflumilast prevents bleomycin- (BLM-) induced lung fibrosis in animal models. However, its mechanism of action remains unknown. We investigated whether roflumilast N-oxide (RNO), the active metabolite of roflumilast, can modulate in vitro the oxidative effects of B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vecchio, Daniela, Acquaviva, Alessandra, Arezzini, Beatrice, Tenor, Hermann, Martorana, Piero A., Gardi, Concetta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763264/ https://www.ncbi.nlm.nih.gov/pubmed/24027357 http://dx.doi.org/10.1155/2013/745984

Ejemplares similares

Roflumilast Prevents the Metabolic Effects of Bleomycin-Induced Fibrosis in a Murine Model
por: Milara, Javier, et al.
Publicado: (2015)

Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice
por: Martorana, Piero A, et al.
Publicado: (2008)

Roflumilast-N-oxide Induces Surfactant Protein Expression in Human Alveolar Epithelial Cells Type II
por: Höhne, Kerstin, et al.
Publicado: (2012)

Roflumilast Inhibits Respiratory Syncytial Virus Infection in Human Differentiated Bronchial Epithelial Cells
por: Mata, Manuel, et al.
Publicado: (2013)

Roflumilast Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α and Chemokine Production by Human Lung Parenchyma
por: Buenestado, Amparo, et al.
Publicado: (2013)

Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist
por: Salvator, Hélène, et al.
Publicado: (2020)

Roflumilast Reduced the IL-18-Induced Inflammatory Response in Fibroblast-Like Synoviocytes (FLS)
por: Zhong, Bing, et al.
Publicado: (2021)

Cigarette Smoke Affects Keratinocytes SRB1 Expression and Localization via H(2)O(2) Production and HNE Protein Adducts Formation
por: Sticozzi, Claudia, et al.
Publicado: (2012)

Correction: Cigarette Smoke Affects Keratinocytes SRB1 Expression and Localization via H(2)O(2) Production and HNE Protein Adducts Formation
por: Sticozzi, Claudia, et al.
Publicado: (2020)

Roflumilast N-Oxide Prevents Cytokine Secretion Induced by Cigarette Smoke Combined with LPS through JAK/STAT and ERK1/2 Inhibition in Airway Epithelial Cells
por: Victoni, Tatiana, et al.
Publicado: (2014)

Effects of NOX1 on fibroblastic changes of endothelial cells in radiation-induced pulmonary fibrosis
por: CHOI, SEO-HYUN, et al.
Publicado: (2016)

Roflumilast in COPD: a Brazilian perspective
por: Stirbulov, Roberto, et al.
Publicado: (2015)

Vulnerable COPD patients with comorbidities: the role of roflumilast
por: Lipari, Melissa, et al.
Publicado: (2014)

Efficacy and Safety of Roflumilast in Korean Patients with COPD
por: Lee, Jae Seung, et al.
Publicado: (2016)

Migratory marker expression in fibroblast foci of idiopathic pulmonary fibrosis
por: Chilosi, Marco, et al.
Publicado: (2006)

New therapeutic options in the management of COPD – focus on roflumilast
por: Antoniu, Sabina Antonela
Publicado: (2011)

Roflumilast: a review of its use in the treatment of COPD
por: Wedzicha, Jadwiga A, et al.
Publicado: (2016)

Roflumilast partially reverses smoke-induced mucociliary dysfunction
por: Schmid, Andreas, et al.
Publicado: (2015)

Does roflumilast induce phagocytic activity in COPD patients?
por: Ghosh, Baishakhi, et al.
Publicado: (2015)

Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap
por: Zhang, Xiaoli, et al.
Publicado: (2018)

Considerable improvement in hidradenitis suppurativa with oral roflumilast therapy
por: Ring, Hans Christian, et al.
Publicado: (2022)

Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
por: Gauvreau, Gail M, et al.
Publicado: (2011)

Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD
por: Giembycz, Mark A, et al.
Publicado: (2010)

Roflumilast Suppresses Adipogenic Differentiation via AMPK Mediated Pathway
por: Xu, Wan, et al.
Publicado: (2021)

Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts
por: Tannheimer, Stacey L, et al.
Publicado: (2012)

NOX4 downregulation leads to senescence of human vascular smooth muscle cells
por: Przybylska, Dorota, et al.
Publicado: (2016)

Di-Tyrosine Crosslinking and NOX4 Expression as Oxidative Pathological Markers in the Lungs of Patients with Idiopathic Pulmonary Fibrosis
por: Blaskovic, Sanja, et al.
Publicado: (2021)

Roflumilast, a type of phosphodiesterase 4 inhibitor, can reduce intestinal injury caused by sepsis
por: Zhang, Zhongyuan, et al.
Publicado: (2021)

Roflumilast reduces myocardial ischemia reperfusion injury in vivo and in vitro by activating the AMPK signaling pathway
por: Liao, Bo, et al.
Publicado: (2023)

Rapid Liquid Chromatographic Method for the Determination of Roflumilast in the Presence of Degradation Products
por: Barhate, V D, et al.
Publicado: (2010)

Risk factors for the discontinuation of roflumilast in patients with chronic obstructive pulmonary disease
por: Kim, Kyung Hoon, et al.
Publicado: (2017)

Effect and safety of roflumilast for chronic obstructive pulmonary disease in Chinese patients
por: Liu, Dong-yang, et al.
Publicado: (2018)

Adherence to roflumilast under dose-escalation strategy in Korean patients with COPD
por: Park, Tai Sun, et al.
Publicado: (2019)

Can roflumilast become steroid-sparing alternative in the treatment of COVID-19?
por: Shah, Chirag A.
Publicado: (2020)

Rectal roflumilast improves trinitrobenzenesulfonic acid-induced chronic colitis in rats
por: Shaikh-Omar, A., et al.
Publicado: (2022)

Prostaglandin E2 (PGE2) and Roflumilast Involvement in IPF Progression
por: Moshkovitz, Noa, et al.
Publicado: (2023)

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts
por: Liang, Shuang, et al.
Publicado: (2016)

Tacrolimus Increases Nox4 Expression in Human Renal Fibroblasts and Induces Fibrosis-Related Genes by Aberrant TGF-Beta Receptor Signalling
por: Kern, Georg, et al.
Publicado: (2014)

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation
por: Lan, Tian, et al.
Publicado: (2015)

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4
por: Hanley, Christopher J, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0oeomnvk524m773qkepf024k8j