Redox-Linked Domain Movements in the Catalytic Cycle of Cytochrome P450 Reductase

NADPH-cytochrome P450 reductase is a key component of the P450 mono-oxygenase drug-metabolizing system. There is evidence for a conformational equilibrium involving large-scale domain motions in this enzyme. We now show, using small-angle X-ray scattering (SAXS) and small-angle neutron scattering, t...

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Detalles Bibliográficos
Autores principales: Huang, Wei-Cheng, Ellis, Jacqueline, Moody, Peter C.E., Raven, Emma L., Roberts, Gordon C.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763376/
https://www.ncbi.nlm.nih.gov/pubmed/23911089
http://dx.doi.org/10.1016/j.str.2013.06.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763376/
https://www.ncbi.nlm.nih.gov/pubmed/23911089
http://dx.doi.org/10.1016/j.str.2013.06.022

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