Cargando…

Redox-Linked Domain Movements in the Catalytic Cycle of Cytochrome P450 Reductase

NADPH-cytochrome P450 reductase is a key component of the P450 mono-oxygenase drug-metabolizing system. There is evidence for a conformational equilibrium involving large-scale domain motions in this enzyme. We now show, using small-angle X-ray scattering (SAXS) and small-angle neutron scattering, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Wei-Cheng, Ellis, Jacqueline, Moody, Peter C.E., Raven, Emma L., Roberts, Gordon C.K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763376/ https://www.ncbi.nlm.nih.gov/pubmed/23911089 http://dx.doi.org/10.1016/j.str.2013.06.022

Ejemplares similares

Orchestrated Domain Movement in Catalysis by Cytochrome P450 Reductase
por: Freeman, Samuel L., et al.
Publicado: (2017)

Solution structure of the cytochrome P450 reductase–cytochrome c complex determined by neutron scattering
por: Freeman, Samuel L., et al.
Publicado: (2018)

Domain Motion in Cytochrome P450 Reductase: CONFORMATIONAL EQUILIBRIA REVEALED BY NMR AND SMALL-ANGLE X-RAY SCATTERING
por: Ellis, Jacqueline, et al.
Publicado: (2009)

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain
por: Burris-Hiday, Sarah D., et al.
Publicado: (2023)

Liver microsomal lipid enhances the activity and redox coupling of colocalized cytochrome P450 reductase‐cytochrome P450 3A4 in nanodiscs
por: Liu, Kang‐Cheng, et al.
Publicado: (2017)

Coupling of Redox and Structural States in Cytochrome P450 Reductase Studied by Molecular Dynamics Simulation
por: Iijima, Mikuru, et al.
Publicado: (2019)

The Flavin-Containing Reductase Domain of Cytochrome P450 BM3 Acts as a Surrogate for Mammalian NADPH-P450 Reductase
por: Park, Seon-Ha, et al.
Publicado: (2012)

Conformational Rearrangements in the Redox Cycling of NADPH-Cytochrome P450 Reductase from Sorghum bicolor Explored with FRET and Pressure-Perturbation Spectroscopy
por: Zhang, Bixia, et al.
Publicado: (2022)

How Does the Reductase Help To Regulate the Catalytic Cycle of Cytochrome P450 3A4 Using the Conserved Water Channel?
por: Fishelovitch, Dan, et al.
Publicado: (2010)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Conformational Landscape of Cytochrome P450 Reductase Interactions
por: Sellner, Manuel, et al.
Publicado: (2021)

Cytochrome P450 reductase (POR) as a ferroptosis fuel
por: Koppula, Pranavi, et al.
Publicado: (2021)

Cytochrome b5 reductases: Redox regulators of cell homeostasis
por: Hall, Robert, et al.
Publicado: (2022)

Nitroreduction of flutamide by Cunninghamella elegans NADPH: Cytochrome P450 reductase
por: Khan, Mohd Faheem, et al.
Publicado: (2022)

Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling
por: Lopez, Melina, et al.
Publicado: (2022)

Biochemical and structural insights into the cytochrome P450 reductase from Candida tropicalis
por: Ebrecht, Ana C., et al.
Publicado: (2019)

Evolution of Cytochrome P450 Enzymes and Their Redox Partners in Archaea
por: Ngcobo, Phelelani Erick, et al.
Publicado: (2023)

Co-expression of active human cytochrome P450 1A2 and cytochrome P450 reductase on the cell surface of Escherichia coli
por: Quehl, Paul, et al.
Publicado: (2016)

Cytochrome P450 Reductase: A Harbinger of Diffusible Reduced Oxygen Species
por: Manoj, Kelath Murali, et al.
Publicado: (2010)

Contribution of NADPH-cytochrome P450 Reductase to Azole Resistance in Fusarium oxysporum
por: He, Dan, et al.
Publicado: (2021)

Cloning and Functional Characterization of NADPH-Cytochrome P450 Reductases in Aconitum vilmorinianum
por: Cheng, Jingping, et al.
Publicado: (2023)

Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells
por: Heintze, Tamara, et al.
Publicado: (2021)

Application of hepatic cytochrome b(5)/P450 reductase null (HBRN) mice to study the role of cytochrome b(5) in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine
por: Reed, Lindsay, et al.
Publicado: (2019)

Genomic and Bioinformatic Analysis of NADPH-Cytochrome P450 Reductase in Anopheles stephensi (Diptera: Culicidae)
por: Suwanchaichinda, C., et al.
Publicado: (2014)

Engineering of daidzein 3’-hydroxylase P450 enzyme into catalytically self-sufficient cytochrome P450
por: Choi, Kwon-Young, et al.
Publicado: (2012)

The Role of Cytochromes P450 and Aldo-Keto Reductases in Prognosis of Breast Carcinoma Patients
por: Hlaváč, Viktor, et al.
Publicado: (2014)

Drug-enhanced carbon monoxide production from heme by cytochrome P450 reductase
por: Vukomanovic, Dragic, et al.
Publicado: (2017)

Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding
por: Esteves, Francisco, et al.
Publicado: (2020)

Molecular Cloning and Identification of NADPH Cytochrome P450 Reductase from Panax ginseng
por: Zou, Xian, et al.
Publicado: (2021)

Cytochrome P450 Monooxygenase/Cytochrome P450 Reductase Bi-Enzymatic System Isolated From Ilex asprella for Regio-Specific Oxidation of Pentacyclic Triterpenoids
por: Li, Le, et al.
Publicado: (2022)

Real‐time analysis of conformational control in electron transfer reactions of human cytochrome P450 reductase with cytochrome c
por: Hedison, Tobias M., et al.
Publicado: (2015)

The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners
por: Esteves, Francisco, et al.
Publicado: (2020)

The catalytic function of cytochrome P450 is entwined with its membrane-bound nature
por: Barnaba, Carlo, et al.
Publicado: (2017)

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleT(JE)
por: Matthews, Sarah, et al.
Publicado: (2017)

Cytochrome b(5) impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b(5)/P450 reductase null (HBRN) mice
por: Reed, Lindsay, et al.
Publicado: (2018)

Evaluation of RNA-knockdown strategies for modulation of cytochrome P450 reductase activity in mouse hepatocytes
por: Mackenzie, Neil CW, et al.
Publicado: (2010)

H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation
por: Tsai, Fu-Ming, et al.
Publicado: (2015)

NADPH–Cytochrome P450 Reductase Mediates the Resistance of Aphis (Toxoptera) citricidus (Kirkaldy) to Abamectin
por: Jing, Tian-Xing, et al.
Publicado: (2018)

Corrigendum: The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners
por: Esteves, Francisco, et al.
Publicado: (2020)

Probing the Single Key Amino Acid Responsible for the Novel Catalytic Function of ent-Kaurene Oxidase Supported by NADPH-Cytochrome P450 Reductases in Tripterygium wilfordii
por: Su, Ping, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_a20cbk00g72melmgllh58f22ej