Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis

Aurora B kinase is an integral regulator of cytokinesis, as it stabilizes the intercellular canal within the midbody to ensure proper chromosomal segregation during cell division. Here we identified that the ubiquitin E3 ligase complex SCF(FBXL2) mediates Aurora B ubiquitination and degradation with...

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Detalles Bibliográficos
Autores principales: Chen, B B, Glasser, J R, Coon, T A, Mallampalli, R K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763433/
https://www.ncbi.nlm.nih.gov/pubmed/23928698
http://dx.doi.org/10.1038/cddis.2013.271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763433/
https://www.ncbi.nlm.nih.gov/pubmed/23928698
http://dx.doi.org/10.1038/cddis.2013.271

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