Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells

Topoisomerases-IIα (TOP2A) enzyme is essential for cell viability due to its fundamental role in DNA metabolism and in chromatin organization during interphase and mitosis. TOP2A expression is finely regulated at the transcriptional level through the binding of the CCAAT-transcription factor NF-Y to...

Descripción completa

Detalles Bibliográficos
Autores principales: Belluti, S, Basile, V, Benatti, P, Ferrari, E, Marverti, G, Imbriano, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763449/
https://www.ncbi.nlm.nih.gov/pubmed/23928695
http://dx.doi.org/10.1038/cddis.2013.287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763449/
https://www.ncbi.nlm.nih.gov/pubmed/23928695
http://dx.doi.org/10.1038/cddis.2013.287

Ejemplares similares