Multiple mechanisms repress N-Bak mRNA translation in the healthy and apoptotic neurons

N-Bak is a neuron-specific BH3-only splice variant of pro-apoptotic Bcl-2 family member Bak. We have shown that its mRNA is stable in the neurons, whereas the protein cannot be detected by antibodies, suggesting a strong translational arrest of the mRNA. Here we identify two regulatory elements in t...

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Detalles Bibliográficos
Autores principales: Jakobson, M, Llano, O, Palgi, J, Arumäe, U
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763458/
https://www.ncbi.nlm.nih.gov/pubmed/23969856
http://dx.doi.org/10.1038/cddis.2013.297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763458/
https://www.ncbi.nlm.nih.gov/pubmed/23969856
http://dx.doi.org/10.1038/cddis.2013.297

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