CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex

In the lymph node (LN) environment, chronic lymphocytic leukemia (CLL) cells display increased NF-κB activity compared with peripheral blood CLL cells, which contributes to chemoresistance. Antagonists of cellular inhibitor of apoptosis proteins (cIAPs) can induce apoptosis in various cancer cells i...

Descripción completa

Detalles Bibliográficos
Autores principales: Maas, C, Tromp, J M, van Laar, J, Thijssen, R, Elias, J A, Malara, A, Krippner-Heidenreich, A, Silke, J, van Oers, M HJ, Eldering, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763465/
https://www.ncbi.nlm.nih.gov/pubmed/23990022
http://dx.doi.org/10.1038/cddis.2013.305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763465/
https://www.ncbi.nlm.nih.gov/pubmed/23990022
http://dx.doi.org/10.1038/cddis.2013.305

Ejemplares similares