TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

Chain-terminating nucleoside analogs (CTNAs) that cause stalling or premature termination of DNA replication forks are widely used as anticancer and antiviral drugs. However, it is not well understood how cells repair the DNA damage induced by these drugs. Here, we reveal the importance of tyrosyl–D...

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Detalles Bibliográficos
Autores principales: Huang, Shar-yin N., Murai, Junko, Dalla Rosa, Ilaria, Dexheimer, Thomas S., Naumova, Alena, Gmeiner, William H., Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763526/
https://www.ncbi.nlm.nih.gov/pubmed/23775789
http://dx.doi.org/10.1093/nar/gkt483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763526/
https://www.ncbi.nlm.nih.gov/pubmed/23775789
http://dx.doi.org/10.1093/nar/gkt483

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