Loss of heterozygosity preferentially occurs in early replicating regions in cancer genomes

Erroneous repair of DNA double-strand breaks by homologous recombination (HR) leads to loss of heterozygosity (LOH). Analysing 22 392 and 74 415 LOH events in 363 glioblastoma and 513 ovarian cancer samples, respectively, and using three different metrics, we report that LOH selectively occurs in ea...

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Detalles Bibliográficos
Autores principales: Pedersen, Brent S., De, Subhajyoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763542/
https://www.ncbi.nlm.nih.gov/pubmed/23793816
http://dx.doi.org/10.1093/nar/gkt552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763542/
https://www.ncbi.nlm.nih.gov/pubmed/23793816
http://dx.doi.org/10.1093/nar/gkt552

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