Genome-Wide Signatures of Transcription Factor Activity: Connecting Transcription Factors, Disease, and Small Molecules

Identifying transcription factors (TF) involved in producing a genome-wide transcriptional profile is an essential step in building mechanistic model that can explain observed gene expression data. We developed a statistical framework for constructing genome-wide signatures of TF activity, and for u...

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Detalles Bibliográficos
Autores principales: Chen, Jing, Hu, Zhen, Phatak, Mukta, Reichard, John, Freudenberg, Johannes M., Sivaganesan, Siva, Medvedovic, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764016/
https://www.ncbi.nlm.nih.gov/pubmed/24039560
http://dx.doi.org/10.1371/journal.pcbi.1003198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764016/
https://www.ncbi.nlm.nih.gov/pubmed/24039560
http://dx.doi.org/10.1371/journal.pcbi.1003198

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