Age of Onset of RNA Toxicity Influences Phenotypic Severity: Evidence from an Inducible Mouse Model of Myotonic Dystrophy (DM1)

Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults. It is caused by an expanded (CTG)n tract in the 3′ UTR of the Dystrophia Myotonica Protein Kinase (DMPK) gene. This causes nuclear retention of the mutant mRNA into ribonuclear foci and sequestration of interacting RNA-...

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Detalles Bibliográficos
Autores principales: Gladman, Jordan T., Mandal, Mahua, Srinivasan, Varadamurthy, Mahadevan, Mani S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764231/
https://www.ncbi.nlm.nih.gov/pubmed/24039817
http://dx.doi.org/10.1371/journal.pone.0072907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764231/
https://www.ncbi.nlm.nih.gov/pubmed/24039817
http://dx.doi.org/10.1371/journal.pone.0072907

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