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High-resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design

Recent efforts to design de novo or redesign the sequence and structure of proteins using computational techniques have met with significant success. Most, if not all, of these computational methodologies attempt to model atomic-level interactions, and hence high-resolution structural characterizati...

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Detalles Bibliográficos
Autores principales: Dantas, Gautam, Corrent, Colin, Reichow, Steve L., Havranek, James J., Eletr, Ziad M., Isern, Nancy G., Kuhlman, Brian, Varani, Gabriele, Merritt, Ethan A., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764424/
https://www.ncbi.nlm.nih.gov/pubmed/17196978
http://dx.doi.org/10.1016/j.jmb.2006.11.080