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Myc-Dependent Genome Instability and Lifespan in Drosophila

The Myc family of transcription factors are key regulators of cell growth and proliferation that are dysregulated in a large number of human cancers. When overexpressed, Myc family proteins also cause genomic instability, a hallmark of both transformed and aging cells. Using an in vivo lacZ mutation...

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Detalles Bibliográficos
Autores principales:	Greer, Christina, Lee, Moonsook, Westerhof, Maaike, Milholland, Brandon, Spokony, Rebecca, Vijg, Jan, Secombe, Julie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765364/ https://www.ncbi.nlm.nih.gov/pubmed/24040302 http://dx.doi.org/10.1371/journal.pone.0074641

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