Synergistic Re-Activation of Epigenetically Silenced Genes by Combinatorial Inhibition of DNMTs and LSD1 in Cancer Cells

Epigenetic gene silencing, mediated by aberrant promoter DNA hypermethylation and repressive histone modifications, is a hallmark of cancer. Although heritable, the dynamic nature and potential reversibility through pharmacological interventions make such aberrations attractive targets. Since cancer...

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Detalles Bibliográficos
Autores principales: Han, Han, Yang, Xiaojing, Pandiyan, Kurinji, Liang, Gangning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765366/
https://www.ncbi.nlm.nih.gov/pubmed/24040395
http://dx.doi.org/10.1371/journal.pone.0075136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765366/
https://www.ncbi.nlm.nih.gov/pubmed/24040395
http://dx.doi.org/10.1371/journal.pone.0075136

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