Depletion of the cellular antioxidant system contributes to tenofovir disoproxil fumarate - induced mitochondrial damage and increased oxido-nitrosative stress in the kidney

BACKGROUND: Nephrotoxicity is a dose limiting side effect of tenofovir, a reverse transcriptase inhibitor that is used for the treatment of HIV infection. The mechanism of tenofovir nephrotoxicity is not clear. Tenofovir is specifically toxic to the proximal convoluted tubules and proximal tubular m...

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Detalles Bibliográficos
Autores principales: Abraham, Premila, Ramamoorthy, Hemalatha, Isaac, Bina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765371/
https://www.ncbi.nlm.nih.gov/pubmed/23957306
http://dx.doi.org/10.1186/1423-0127-20-61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765371/
https://www.ncbi.nlm.nih.gov/pubmed/23957306
http://dx.doi.org/10.1186/1423-0127-20-61

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